All About Dapoxetine

All About Dapoxetine

Premature ejaculation (PE) is a frustrating sexual disorder in males that may appear during first sexual intercourse or develop later in life. It affects any age group, and it is more common than erectile dysfunction (ED). Dapoxetine is a popular and efficient drug for overcoming this disorder. It also helps prolong sexual intercourse. In this article, you will learn how science explains the of dapoxetine in PE treatment. Is it a unique drug, or does it have its competitors? Let’s find out.

Furiex Pharmaceuticals, Inc. introduced dapoxetine into the US market in May 2010. The drug became a revolutionary solution for PE in males. It was designed by Furiex in cooperation with Alza Corporation and correlated partners.

US license includes recommendations related to using dapoxetine and shows its benefits compared to other drugs with similar ingredients in the identical drug family. The patent is active till 2022. More than 45 countries in the world, including leading and emerging markets, have been sending grants to Furiex for equal patent claims.

Janssen-Cilag (Alza’s partner) presently produces dapoxetine under the brand name Priligy ™ and sells it in numerous markets outside America. The preparation has been distributed among leading members of European Union (Germany, Sweden, Austria, Spain, Italy, Finland, Portugal), South Korea, New Zealand, and Mexico.

Scientific research clearly showed that serotonin played a central role in the timing of ejaculation. Thusly, the method represented in the dapoxetine patent is valuable. Unlike other drugs, which dapoxetine belongs to, its effect on PE is evident even after the first use, allowing to take it on an as-needed basis.

What Is Dapoxetine HCL?

Dapoxetine hydrochloride is a fast-acting serotonin reuptake inhibitor, which is widely used to cure PE and ED in males. This active ingredient can be used by males of 18 to 64 years of age. Inhibitors of this class of drugs are usually used to treat depressive states and multiple psychiatric illnesses.

Dapoxetine is the active ingredient of the Priligy (the brand name of the drug). It is used for chronic and sudden cases of PE. It belongs to SSRI (Selective Serotonin Reuptake Inhibitor) drug class, which has mainly been used for depressive conditions treatment. The tests showed that this medical preparation is highly effective for curing PE in males. Over 50 countries have approved Dapoxetine HCL for sale.

The table represents the trade names by which dapoxetine is known in the following countries of manufacture.

Brand name

CountryForeign name

Generic name

Priligy (dapoxetine)

Latvia, Romania, Poland, Lebanon, Lithuania, Slovakia, Singapore, Bosnia and Herzegovina, Croatia, SwitzerlandDapoxetinum (Latin)Dapoxetine
Priligy (dapoxetine hydrochloride)Belgium, Denmark, Finland, Germany, Austria, Bulgaria, Estonia, France, Hong Kong, Ireland, Malaysia, Mexico, Hungary, Italy, Malta, Netherlands, Portugal, Spain, Switzerland, United Kingdom, New Zealand, South Korea, ThailandDapoxétine (French)

Dapoxetine hydrochloride

Dasutra, Kutub, Xydap, Sustinex

IndiaDapoxetin (German)LY-210448
JoypoxEgypt

LY 210448 HCl

Lagose, Extensil, Prolongal, Precoce

ArgentinaDapoxetina (Spanish)UNII-GB2433A4M3
TD-Pill (dapoxetine and tadalafil combination)India

UNII-U4OHT63MRI

Due to its revolutionary action, an international society does not have a unanimous opinion about it. That is why dapoxetine is not approved for sale in every country. In the countries where it is not certified patients have to buy it overseas.
All About Dapoxetine

Is It Approved by FDA?

The drug was submitted for the Food and Drug Administration (FDA) approval in the USA in December 2004, but it has not been approved yet. It has been in phase III development.e.

DapoxetineIn October 2005 FDA rejected the medicine. Two more clinical tests were done over the next two years. Nevertheless, dapoxetine has not appeared on the US market to date. Complicating issues of approving the procedure are still incomprehensible. The most obvious ones are adverse symptoms and a lack of long-term human testing.

The third phase is a groundbreaking one: the clinical analyses are usually gathered into a big document, which contains extensive information about the approaches and outcomes of all studies, production process and stages, formulation data and expiration date. Passing this stage successfully gives rights to the sponsor to market the drug.

The trials in this phase are the most expensive ones. They demand a lot of time for implementation, especially for chronic illnesses. If the drug is lifesaving, it can be prescribed to some patients on an individual basis until it is approved for public purchasing.

The question, how soon dapoxetine may appear on the US market, is open It is very likely that dapoxetine will not be available in the US in the coming years. It may never receive FDA approval for sale. It should be noted that in most European countries this drug has been successfully selling as of today. Its approval depends on the government politics, especially if the supervisors find more advantages than potential health risks.

Dapoxetine can be the first drug specifically targeted for PE in patients in the USA, where it should be distributed by Ortho-McNeil Pharmaceutical, Inc. Alza press release says that the producers plan to work on the problem mentioned in the FDA document regarding dapoxetine. The process of introducing dapoxetine onto the US Pharmaceutical Market is underway.

Its generic versions have already been successfully produced and are selling today. Those who do not want to wait for the FDA approval may order generic dapoxetine from foreign producers in the countries where dapoxetine has already been certificated.

Dosages

Premature ejaculationDapoxetine tablets come in doses of 30 mg, 60 mg and 90 mg.

30 mg is the most suitable dose for beginners. Minimal dose helps estimate the effectiveness of the remedy in each individual and the influence of side effects on a patient. It may be increased up to 60 mg depending on response and tolerability.

60 mg is the optimal dose. Trials showed that administering the drug in these doses showed the best results in PE treatment with moderate adverse events. It is the most common and successful dosage among patients, and they can tolerate the drug well.

90 mg includes the highest concentration of dapoxetine available at the pharmaceutical market. It can be taken for more powerful effect in PE cure, if the lower doses showed weak effect. Adverse symptoms should be considered as well. If, despite the dapoxetine effectiveness, a patient suffered from severe side effects, he should consult the doctor to seek other solutions.

To get sufficient efficacy from the drug and avoid adverse symptoms, a patient should discuss with his physician the schedule of treatment.

In males with PE concurrent with ED problems dapoxetine can be combined with PDE5 inhibitors. Combination of dapoxetine with such active ingredients as sildenafil, vardenafil, tadalafil show excellent therapeutic effect. Multiple clinical tests proved the feasibility of these substances with dapoxetine. Different ratio of the two active ingredients are designed for better problem solving in a patient. Individual medical consultation before the start of the treatment course is highly recommended.

What Forms Does Dapoxetine Come In?

Dapoxetine is widely available in firm tablet drug form. The rigid tablet contains dapoxetine as a single ingredient. This is a classic tablet form which should be used with water without chewing.

Liquid one is sold for laboratory research only. The bottle of liquid dapoxetine contains 30 mg of the active ingredient. Consumption of this product by human may be harmful if ingested.

Generic dapoxetine is available in other drug forms in combination with different active ingredients, for example Super P Force oral jelly (sildenafil 100mg and dapoxetine 60mg).

For curing ED problems accompanied with PE dapoxetine is highly used as a compound. A few popular drug names and their ratio with dapoxetine are represented in the table.

Dapoxetine and sildenafil

Dapoxetine and Vardenafil

Dapoxetine and tadalafil

Sildigra Super power

(60 mg / 100 mg)

Snovitra Power

(60 mg / 40 mg)

Tada Plus

(30 mg / 20 mg)

Dapoxile

(30 mg / 50 mg)

Snovitra Super Power

(60 mg / 20 mg)

Tadapox

(60 mg / 20 mg)

Super P Force

(60 mg / 100 mg)

Super Valetra
(20 mg / 60 mg)

Tadapox Super

(60 mg / 40 mg)

Suhagra Force

(30 mg / 50 mg)

Super Zhewitra

(60mg / 20 mg)

Extra Super Tadarise

(60 mg / 40 mg)

Patients should receive a proper medical consultation before using any other drugs listed above. They may cause unwanted reactions and side effects. Individual schedule of treatment is highly suggested.

How to Use Dapoxetine Tablets?

Fat foodDapoxetine tablets are very easy to use. The pills can be taken at any time on an as-needed basis. Fat food may delay the absorption of the tablet, but it does not affect its efficacy. Here are a few simple steps how to use dapoxetine:

  1. It is necessary to have a complete medical examination before starting dapoxetine treatment course. A healthcare provider should estimate the patient’s health condition, prescribe the correct dosage of the drug, explain in detail what is dapoxetine, and give detailed instructions on how to take it.
  2. Be sure to inform the healthcare provider about other drugs or other treatments you have been using. Dapoxetine highly interacts with several drug groups, therefore detailed medical consultation is highly recommended. Several medical conditions demand special medical attention. Be sure to inform the medical representative if you experience one of these conditions:
    • fainting tendency;
    • heart diseases;
    • bleeding or clotting problems;
    • epilepsy;
    • psychological disorders (mood swings, dismal mood, obsessiveness, bipolar illness);
    • eye pressure (glaucoma);
    • liver problems;
    • kidney illnesses;
    • dermatological reactions on medical preparations.
  1. Read carefully the medical annotation inside the package. It contains complete information about dapoxetine with the list of possible negative symptoms which might occur during the treatment.
  2. Strictly follow the scheme prescribed by the doctor. The correct dosage should be used 1-3 hours before sexual intercourse. Wash down the tablet with 250 ml of water.
  3. If the prescribed dose appeared weak and ineffective during several days of consumption, a patient should come for medical consultation. Increasing a dose on one’s own initiative is not recommended because bigger dose also increases the risks of side effects.
  4. Dapoxetine should be taken only once in a 24-hour period. The drug should be used on an as-needed basis before planned sex.
  5. Dapoxetine has a bitter taste. There is no need to chew it. It can be taken regardless of the meal time.

Failure to follow medication direction can ruin the drug effect, cause a negative reaction, or even have serious health consequences. In case of any unwanted reaction a patient must see his health care provider immediately.

How and When to Take Dapoxetine for the Best Results?

DoctorDapoxetine is an effective remedy. However, to get the best results from the treatment course, remember the important tips:

  1. After beginning of the treatment course continue seeing your physician to inform him about your health condition, progress, and to monitor side effects if any. Alcohol increases the risk of adverse symptoms like fainting, therefore its consumption with dapoxetine is not recommended.
  2. Recreational drugs may cause serious side effects in combination with dapoxetine. Never use them together!
  3. Due to risk of fainting symptoms after taking dapoxetine, driving and other activities, which demand high concentration, should be postponed for patient’s safety.
  4. Make sure to get a detailed consultation before mixing dapoxetine with other medical preparations.
  5. In case of overdosing call an ambulance or local hospital department immediately. Bring the pack with you, even if the box is empty.
  6. Before your surgery (including dental surgery), inform the specialist that you consume dapoxetine.
  7. Taking expired dapoxetine is not recommended. Contact local pharmacy for utilization of the expired drug.
  8. Never share dapoxetine with other people. The drug should be used individually, even if someone has approximately the same condition.
  9. Keep the tablets out of reach and sight of children in cool dry place away from direct sun rays.
  10. Contact your physician to discuss any problem which occurred during dapoxetine treatment course.
  11. There are many ways how to avoid mild side effects of the drug. Get detailed instructions at the medical center. Stay in touch with your doctor during the whole therapy for successful treatment.

These simple rules will help you receive maximum effect from the tablet and prolong sexual intercourse.

Can Dapoxetine and Sildenafil Be Taken Together?

Priligy and ViagraSometimes ED and PE are concomitant conditions. The question is whether dapoxetine and sildenafil can be taken together. It can not be answered simply because PE may be caused by various reasons: relationship issues or erectile problems.

Some scientific works claim that sildenafil and dapoxetine can not be used together. It is explained by the combined effect, which reduces blood pressure to a low level enough to cause dizziness, fainting and lightheadedness. Medical scientists suggest treating ED first, assuming that during that time PE will be treated by itself as well.

If sildenafil improves erectile function but PE problem still exists, health professionals recommend using non-drug practices for overcoming it. These are preferably relaxation, squeezing techniques, and psychological methods, which include avoiding stressful situations and overcoming lack of communication between partners.

Exercising can be effective but does not always help. A patient may use sildenafil with dapoxetine under a strict doctor’s control only. Both ingredients have a lot of common features. Working with natural mechanisms, they make impact only on the selective brain areas. The latest clinical researches showed a perfect compatibility that can create a new medication. As a result, pharmaceutical market can offer the drug, which contains two active substances: sildenafil and dapoxetine.

Today this combination is manufactured under various names with different ratio of both ingredients. While sildenafil works to achieve and maintain erection, dapoxetine releases tension. A male becomes more comfortable and can have sexual intercourse without unnecessary anxiety.

Preceding concerns were not without a reason, the new drug does have side effects. Though, as tests showed, the conflict of contraindications and damages to the man’s health were not life threatening. Taking two drugs may lessen the combined effect of the substances.

The treatment scheme may include separate drugs with sildenafil (like Viagra) and dapoxetine (like Priligy) or their mix in one tablet (like Viagra Super Force). Regardless of the brand names a patient may use, the combination of sildenafil and dapoxetine shows excellent results in treating ED and PE. Nevertheless, preliminary medical consultation and health care provider’s assistance during the whole treatment course are necessary.

If PE problem is connected with ED problem, then sildenafil should possibly become one and the best remedy for this particular clinical case. The decision about mixing the preparations should be made by doctors based on patient’s medical history.

Is It Safe?

Central nervous systemEffectiveness and safeness of dapoxetine in PE therapy has been investigated by such reputable institutions as EMBASE (world’s most comprehensive biomedical literature database), MEDLINE, Web of Science, and PICA. Primary scientific community represented by international and local foundations confirmed that dapoxetine is indeed a strong and safe medical preparation. The approbations showed that dapoxetine in doses of 30 and 60 mg were positively sustained with minimal possibility of severe side effects manifestations. More than half males reported mild forms of gastrointestinal and central nervous system problems.

A careful attention over the whole period of dapoxetine course was given to cardiovascular changes in patients, since the syncope case had been recited. Throughout all five tests, loss of consciousness happened in 0.06% and 0.23% of cases after using dapoxetine 30 mg and dapoxetine 60 mg respectively. With high probability this adverse event may occur after taking the first dose of the drug. The tests showed 0.19% cases which happened after the first dose, and 0.08% after subsequent ones. Findings of dapoxetine developmental program demonstrate that the ingredient is related to vasovagal-mediated (neurocardiogenic) syncope. Other crucial vascular cardiac negative reactions were not diagnosticated.

Most drugs of SSRI class may cause neurocognitive unwanted changes in patients with psychosocial disabilities. Clinical tests showed that dapoxetine does not affect the mood, and it does not cause anxiety and self-destructive streaks. Dapoxetine on-demand doses for PE may minimize the risk of withdrawal symptoms.

Thusly, all this evidence shows safeness of dapoxetine. But the final word on that is given to FDA, which has not approved this preparation yet. Only due to this reason the medics of the USA, Canada and United Kingdom (the countries where dapoxetine is not approved for sale yet) may disapprove it to patients.

The quality of generic versions depends on how reputable the producer is and if its product was certificated by the local government. It is highly suggested to buy generic versions of dapoxetine only from trusted sources who sell high quality medications. Using mislabeled drugs may be dangerous for your health.

Is It Used for Depression?

Created in 2003, dapoxetine was initially aimed for depression and mental disorders treatment. The preparation did not show positive results in depression therapy and was shelved until its PE effect was discovered. During clinical trials the results in ejaculation problems treatment were awesome.

Depression

Dapoxetine may potentially cause side effects peculiar to SSRI drugs as far as it belongs to this class. But this preparation is mostly obtained for treating PE only.

Even more, dapoxetine is contraindicated for people who suffer from such psychological disorders as:

  • bipolar and related disorders;
  • mania and hypomania;
  • major depressive episode;
  • schizophrenia and other psychiatric illnesses.

Dapoxetine is a specific remedy created for solving PE problem in males. Using it for other purposes is not recommended.

How Does Dapoxetine Work?

The clear biochemical mechanism of dapoxetine action is still ill-defined. With a high probability in PE case it is attributed to the breakage of the serotonin reuptake by the neuronal cells with the forthcoming neurotransmitter enhancing on pre- and postsynaptic receptors.

The ejaculation mechanism is mostly manipulated by the excitatory system or, more precisely, by the part of the nervous system that accelerates the heart rate, constricts blood vessels, and raises blood pressure (sympathetic nervous system). The ejaculatory trajectory sets in from a spinal reflex center, mediated by the cerebral trunk, which is influenced initially by a number of nuclei in the brain. Postganglionic sympathetic nervous fibers innervate gone cysts, deferent duct, prostate gland, urethra muscles and neck of urinary bladder, calling their synchronized cutdown for ejaculation achievement.

Dapoxetine definitely impacts ejaculation reflex, prolonging the latency period and reducing the duration of the reflector impulse. The stimulation pulse, which activates ejaculation, is generated in cerebrospinal nerve center, which is controlled by a few niduses of the brain cord through the cerebral trunk.

The function of dapoxetine consists in preventing the reuptake of serotonin and the subsequent action enhancement of the neurotransmitter receptors. Dapoxetine inhibits the ejaculatory expulsion reflex by acting at a supra spinal level with the lateral paragigantocellular nucleus as a necessary brain structure for the effect. Postganglionic sympathetic fibres that innervate the seminal vesicles, prostate, bulbourethral muscles, and bladder neck cause them to contract in a coordinated fashion to achieve ejaculation. Dapoxetine modulates this ejaculatory reflex, causing an increase in pudendal motoneuron reflex discharge (PMRD) latency and a reduction in PMRD duration.

It relieves tension and improves patient’s general mood. It works only with the brain cells which are responsible for PE, without affecting the whole brain.

This unique formula distinguishes dapoxetine from other drugs of SSRI family group, which are used for mental disorders. Working precisely on ejaculation mechanism it prolongs the time of emission of seminal fluid, which is the main purpose of dapoxetine.

How Long Does It Stay in Your System?

Renal impairmentDapoxetine is quickly absorbed. Maximal concentration is achieved within 1-2 hours after consumption. Absolute bioavailability is 42% raging from 15% to 76%.

Fattening food may affect dapoxetine concentration depending on how long it stays in your system. High fat meals frugally reduce dapoxetine concentration without affecting the total absorption level. Dapoxetine can be used regardless of the meal time.

Dapoxetine is metabolized by the multiple ferments of liver and kidneys. The metabolites of dapoxetine are moved out with urine. Unconverted substance in urine has not been discovered. The low concentration of dapoxetine in blood (5%) within 24-hours period testifies that it is egested quickly out of the body. Every usage allows minimal accumulation of dapoxetine, the terminal half-life is about 19 hours.

Single usage of dapoxetine 60 mg has not showed any statistically authentic distinction between Caucasian, Black, Hispanic and Asian races. Although, Japanese race is characterized by higher plasma levels (20%) comparing to Caucasian (10%) due to lower body weight. This fact is not expected to have a meaningful clinical effect.

There is no significant difference between using dapoxetine by different age groups. Patients with severe renal impairment were not thoroughly tested, doses should be used carefully.

Side Effects of Dapoxetine

Medical preparations may cause side effects, and dapoxetine is not an exception. The most frequent adverse events known after taking dapoxetine is dizziness, headache and sickness. Adverse effects is the main reason why this preparation has not been approved in the USA, so let’s examine this point more carefully. The table represents the names and statistics of side effects in patients.

Very common (1 in 10 people)

Common (1 in 10 and 1 in 100 people)Uncommon (1 in 100 and 1 in 1000 people)

Rare (1 in 1000 and 1 in 10 000 people)

Vertigo

DisturbanceLightheadedness

Sleep attacks

Nervousness

Excitation

Unrest

Faint

Concentration troubles

Sleeplessness

Mood swings

Parasomnia

Low libido

Depressive states

Migraine

Erectile problems

Dizzy feeling after physical overwork

Tiredness

Anxiety

Drowsy feeling

Oscitation

Disconcerted feeling

Shaking

Pricky sensation

Weakness

Ear ringing or buzzing

Blurred vision

Panic

Sick feeling

Nasal congestion

Urgent need for toilet
Stomach upsets

Tumultuous dreams

Emesis

Costiveness

Irregular heartbeat

Abdominal discomfort

Flatulence

Enlarged pupils

Thirst

Hyperhidrosis

Bruxism

Blushing

Hypertension

The list of adverse events is incomplete. To avoid adverse symptoms manifestations it is important to follow the treatment schedule and abide by the following rules:

  1. Reduce driving and operating hazardous machinery, especially in case of dizzy feeling after taking dapoxetine. Check out first how the body reacts to the new preparation.
  2. Avoid alcoholic beverages because they increase the risks of the side effects.
  3. Always drink a full glass of water along with the tablet and stand up slowly if you have been sitting or lying for a long time.
  4. If dizziness becomes annoying, a patient should lie down or sit down, put his head between his legs until the symptoms pass.
  5. Do not take dapoxetine with recreational drugs (ecstasy, LSD, amyl nitrate, narcotics or benzodiazepines).

Always consult with a healthcare provider regarding any abnormal conditions during the treatment. If the risks overweigh the benefits, a healthcare provider will suggest giving up the medicine or switching to a different drug.

Side effects of dapoxetineImportant note: in case of sudden reducing SSRI drugs they may cause the following symptoms:

  • dysphoria;
  • irritation;
  • agitation;
  • dizziness;
  • sensory impairment (for example, paraesthesia);
  • anxiety;
  • confusion of consciousness;
  • migraine;
  • lethargy;
  • emotional lability;
  • insomnia;
  • hypomania.

Dapoxetine belongs to an SSRI class group, and its reaction to sudden reducing was clinically tested. Researches showed that after 62 days of taking the preparation (or longer) the most frequent symptoms were sleeplessness and dizziness in mild and moderate form. Therefore, sudden reducing should go smoothly.

What If I Take Dapoxetine with …

The medical annotation for dapoxetine includes strict admonitions against consuming it with herbal remedies that prevent the activity of the Cytochrome P450 (CYP) 3A4 ferment.

The effect of the daily intake of grapefruit and pomegranate juice on the work of dapoxetine was tested during a 3-way crossover study. It appeared that grapefruit increases the dapoxetine plasma concentration and prolonged its elimination half-life. Slight, but not statistically significant changes were discovered after pomegranate juice intake.

The impact of juices is mild. Many more concerns call their parallel usage with dapoxetine into question. Therefore, grapefruit and pomegranate are not recommended due to the accumulation of the active ingredient and difficult elimination of it from the organism. Such processes may become a reason for overdose and provoke side effect manifestations.

Consult with medics in private regarding the usage of caffeine, herbal supplements, and nutraceuticals.

Alcohol

AlcoholThe combination of dapoxetine with alcohol may intensify the ethanol activity on the central nervous system and increase neurocardiogenic side effects, like syncope which, in turn, increases the risk of sudden traumatic accidents. Thus, patients should avoid using alcohol during the dapoxetine curing course.

One-time consumption of ethanol (0.5 g/kg which is about 2 units) did not affect the pharmacokinetics of dapoxetine 60 mg. Simultaneous consuming of dapoxetine and alcohol caused drowsy feelings, reduced the vigil level, delayed reflexes, and changed judgment.

Food

High fat meals make a modest impact on an organism in conjunction with dapoxetine which actually consist in a delay of the working time. It is explained by the complicated digestion process which takes more time. Trials showed that the tablet started working within 30 minutes after the patient ate the food which slowed absorption. However, the general work of dapoxetine goes without significant changes.

A few examples of high fat food which delay the digestion process are below:

  • fried chicken;
  • bacon cheeseburger;
  • french fries;
  • fried cheese sticks;
  • pizza;
  • Caesar salad;
  • nachos;
  • cheesecake;
  • hot dogs;
  • beef burrito;
  • chicken nuggets;
  • taco.

Other Medications

Interaction with alcohol, tablets and grapefruit

Dapoxetine drastically interacts with a few medication groups. The list below shows the largest drug families and the outcome of their cooperation with dapoxetine. It is far from complete. For the detailed info regarding every particular drug and how does it work in combination with dapoxetine, a patient should refer to a healthcare provider:

  1. Monoamine oxidase inhibitors (MAOIs). Patients who received SSRI and MAOIs simultaneously had serious and sometimes lethal reactions, for example hyperthermia, rigidity, myoclonus, mental health changes including distraction which leads to delirium and coma. These reactions may appear in those who reduced the SSRI course and started an MAOI cure recently. In some cases the symptoms were similar to neuroleptic malignant syndrome. These two drugs increase blood pressure and caused agitated behavior. Dapoxetine is strictly forbidden for usage during the 14-day period after stopping the MAOI course. MAO inhibitors are forbidden for 7 days after stopping dapoxetine.
  2. Thioridazine. SSRI inhibit CYP2D6 ferment and delay thioridazine metabolism. Dapoxetine is forbidden for parallel consumption with dapoxetine and within 14 days after stopping a thioridazine course. Thioridazine is forbidden for a week after dapoxetine rejection.
  3. Drugs with serotoninergic activity: L-tryptophan, triptan, tramadol, linezolid, lithium, preparations on the base of hypericum perforatum (St John’s wort). Their combination with dapoxetine increases the frequency of serotonergic side effects. Dapoxetine can be used 2 weeks after reducing these family drugs. Serotoninergic remedies should be taken not earlier than 1 week after dapoxetine rejection.
  4. CYP3A4 inhibitors: ketoconazole, itraconazole, ritonavir, saquinavir, telithromycin, nefazodone, nelfinavir, atazanavir. Simultaneous treatment of dapoxetine with these drugs is forbidden. Moderate inhibitors of CYP3A4 (erythromycin, clarithromycin, fluconazole, amprenavir, fosamprenavir, aprepitant, verapamil, diltiazem) increase the level of dapoxetine systemic exposure. Maximal dose of dapoxetine should be bordered to 30 mg.
  5. CYP2D6 inhibitors. Dapoxetine 60 mg should be cautiously used in people with low CYP2D6 activity level.
  6. A-adrenergic receptors (tamsulosin) should be used carefully in combination with dapoxetine due to low tolerance of patients to orthostatic hypotension.

Dapoxetine Alternatives

Alternative of dapoxetine should be considered any drug from the SSRI drug group. However, it must be noted that similar is only their mechanism of action, while they are different in strength, duration, working start, and side effects.

SSRI drug groupThe most famous analogues of dapoxetine are:

  • sertraline;
  • fluvoxamine;
  • fluoxetine (Prozac);
  • paroxetine;
  • escitalopram;
  • citalopram;
  • indalpine;
  • zimelidine;
  • panuramine;
  • cericlamine;
  • femoxetine.

A remarkable place take PDE5 inhibitors which can be a decent alternative of dapoxetine, too. They are:

They have similar pharmacological properties and therapeutic effects. Along with PE, they treat ED problems, normalizing the potency and genital abnormalities in men.

Remember that dapoxetine is an active ingredient which is produced under multiple brand names. All drugs with the same active ingredient may be considered as alternatives, as well.

Dapoxetine Vs Viagra (Sildenafil)

Erectile dysfunctionViagra (sildenafil) is a brand drug for treating ED problems. While dapoxetine belongs to the SSRI family of drugs, sildenafil belongs to PDE5 inhibitors. The data about successful treatment of PE by sildenafil is very limited.

Some users inform that after taking Viagra, PE problems stopped bothering them. But this information needs more research. Doctors say that delayed ejaculation may be an adverse reaction of sildenafil which is not far enough to say that Viagra treats PE. Dapoxetine is a drug designed especially for PE recovery, and its action is directed to solve this particular problem.

Across one clinical trial, it was found that 50 mg of sildenafil is more effective for curing PE as compared to 20 mg of paroxetine. During half a year, 180 healthy males divided into 3 groups took sildenafil, dapoxetine, and used squeezing techniques, respectively. Sildenafil showed significantly different results, proving its efficacy comparing to paroxetine and squeezing methods. This curious fact demands more research and scientific proof regarding effectiveness of Viagra for PE treatment.

Being preparations for different purposes, dapoxetine and sildenafil perfectly complete each other. Across another clinical test, dapoxetine, sildenafil, and their combination were all thoroughly checked. 150 males without ED were tested from March 2015 to May 2016. The groups of men received 30 mg of dapoxetine, 50 mg of sildenafil citrate, and a combo of dapoxetine (30 mg) with sildenafil citrate (50 mg) for 6 weeks.

All groups significantly improved their satisfaction score after treatment. The combo group showed the best result. This means that combining sildenafil with dapoxetine therapy can perfectly improve patients with PE without ED problems, comparing to a single usage of dapoхetine alone or sildenafil with tolerated adverse events.

Cialis (Tadalafil)

Cialis tabsCialis is a brand drug with the active ingredient tadalafil which is used for ED, pulmonary hypertension, and benign prostatic hyperplasia treatment. Its action is similar to such PDE5 inhibitors as Viagra and Levitra. This drug was approved by the FDA in the USA in 2003 as an ED cure. It can be used daily or on an on-demand basis. The approval for the treatment of pulmonary arterial hypertension was given by the FDA in 2009.

This drug has received the name «weekend pill» for its prolonged activity time: up to 36 hours while other medical preparations of this drug family work only 5 hours.

The main condition for drug work is preliminary the sexual stimulation of the phallus. This condition makes brain cells pass signals to blood vessels in the penis area and enlarge them. Massive bloodflow provides a perfect erection. The dosage should be taken once in a 24-hour period. It also may cause side effects (fainting, sickness, long-lasting erection, and many more). It also interacts with several drug groups. Therefore, this is a prescription drug which should be used under strict doctor’s control.

Cialis generic tabs are available, too. They contain the same active ingredient, tadalafil. The price for generics is very cheap which allows regular usage without significant expenses.

The effectiveness of this drug has been checked for many years of practice. It is not weird as the remedy has been known in the USA for more than 10 years. It is the third pill after Viagra and Levitra represented for ED cure. This preparation is awesomely popular among ED patients and has gathered a lot of positive reviews.

This preparation is available in our drug store ViagraBit in different dosages: 2.5 mg, 5 mg, 10 mg, 20 mg, 40 mg, and 60 mg. Different amounts of tabs inside the package helps to choose the best option for individual cure. Visit our catalogue for more information.

Dapoxetine Vs Paroxetine

ParoxetineParoxetine, manufactured under the brands Brisdelle, Paxil, Paxil CR, and Pexeva, is an antidepressant drug used for the treatment of various depressive conditions, panic states, social anxiety problems, and many other psychological deviations. Like dapoxetine, it belongs to the SSRI class. During FDA checking, this paroxetine has received the black box warning which means that side effects may be dangerous for patients’ health and increase suicidal thoughts and behavior.

Unlike dapoxetine, paroxetine was initially created for the treatment of physiological disorders. Delayed ejaculation is a side effect of this antidepressant which is used in therapeutic purposes for PE sufferers. There is much scientific data regarding the comparison of the two preparations. During the first one, 150 married males from 30-36 y.o. with stable relations and constant PE were divided into 3 groups. The first one received 30 mg dapoxetine, the second one got 60 mg of dapoxetine, and the third one had 20 mg paroxetine once a day 1-3 hours before planned sexual intercourse for a month.

Within 30 days, the IELT index (intravaginal ejaculatory latency time) increased in all groups: 117% after dapoxetine 30 mg, 170% after dapoxetine 60 mg, and 117% after paroxetine 20 mg. This means that the low doses of dapoxetine and paroxetine work approximately equally, but the best results were achieved after using dapoxetine 60 mg.

During another clinical research, aimed to estimate the efficiency and safeness of dapoxetine and paroxetine, 40 males with PE were involved. The groups of men received 30 mg of dapoxetine, 60 mg of dapoxetine, and 20 mg of paroxetine for 12 weeks, and the results were checked every 2 weeks.

The tests showed increased IELT index (see the table):

Dapoxetine 30 mg

Dapoxetine 60 mg

Paroxetine 20 mg

Before trial

After trialBefore trialAfter trialBefore trial

After trial

IELT (seconds)

46.1±23.2100.2±24.543.5±20.6118.2±40.8

45.2±31.6

It proved higher efficiency of paroxetine, though not without adverse effects (see the diagram).

Fluoxetine Versus Dapoxetine

Fluoxetine capsulesFluoxetine is an antidepressant which belongs to the SSRI drug family and is used for the treatment of depressive states and obsessive-compulsive problems in adults.

During clinical trials, fluoxetine in dose 20 mg was compared to 20 mg of paroxetine and 30 mg of dapoxetine in usage by 170 men of 36 y.o. who suffer from PE. Within 1 month, the tests showed global improvement in all groups, although, the dapoxetine and paroxetine results were better than in the fluoxetine test group. Adverse effects were estimated, too:

  • paroxetine: 8 patients;
  • fluoxetine: 9 patients;
  • dapoxetine: 0 patients.

Across a single test of fluoxetine, 17 patients with PE were examined. The dosage of 20 mg of fluoxetine daily for 1 week and 40 mg afterward showed a good IELT index with such side effects as sickness, migraines, and sleeplessness. Generally this drug was assumed as a safe and effective remedy for the cure of PE. But in the battle of dapoxetine vs fluoxetine the last one fails.

The use of SSRI drugs which control and regulate ejaculation processes may cause negative reactions in other sexual functions in males such as suppressing the libido. In order to smooth both effects, fluoxetine is often used in combination with PDE5 inhibitors. This helps to eliminate unwanted reactions of SSRI antidepressants on males sexual functioning and prolong sexual intercourse. Mixing therapy provides significantly more powerful effects than a single usage of an SSRI drug.

Dapoxetine Reviews & User’s Experience

SexThere are plenty of controversial dapoxetine reviews on the Internet. They include a lot of positive feedback. The perfect effect of the drug makes people order it even from overseas.

Negative reviews take place, too. Ethan Green from the UK writes that the preparation is not easily available in his country. 30 mg of Dapoxetine appeared effective for him, even the small dose taken for several weeks 2 hours before planned intercourse increased the time of sex by 2-8 minutes. Constant headaches were quite bothersome during the treatment course and that was the reason why he did not desire to increase the dose for a more powerful effect. His conclusion is a big concern about the future dapoxetine purchase. Firstly, because of trouble buying the drug, and secondly because of its weak effect and adverse symptoms.

Other patients shared different kinds of problem. After long-lasting tortures with PE, he chose dapoxetine for a cure. The drug helped to prolong the sexual act up to 90 minutes, though he could not ejaculate at all afterward.

One patient who tried to increase intake to 60 mg had nausea afterwards. He enjoyed the powerful effect but continued the cure in standard dose.

The curious thing is that female partners find the dapoxetine effect excellent and often insist on their men using it or place it surreptitiously in their man’s meal. Females often buy dapoxetine as a present for their partners and enjoy extra sensations during sex. Males without severe forms of PE also use it to bring more pleasure to their female partners.

Dapoxetine appeared very effective for people who suffer from lifelong PE, ending sexual acts in 5-7 seconds. While other preparations appeared absolutely ineffective, dapoxetine has prolonged sexual acts by up to 20 minutes.

PE may affect a man at any age. Dapoxetine is the first chemical substance that was designed to specifically target this problem in men. It is assumed to be an effective and safe remedy if a patient follows the recommended dose. Most patients are satisfied with the achieved results. With this medicine, they have overcome PE problems which accompanied them for many years.

Where Can I Buy Dapoxetine in USA?

Dapoxetine has many pros and cons, but nevertheless it stays awesomely popular among users. Due to an absence of FDA approval, it is not allowed to be listed for sale in local USA pharmacies, therefore online orders are the only way to get it. Those who want to buy this preparation should order it from foreign countries where it is licensed and authorized for sale.

Cheap prices for Indian dapoxetine makes it convenient for regular treatment. The table represents the costs for the most popular brands of the generic drug.

Indian trade mark

ProducerAmount of tabs in the packagePrice in India for the package in USD (converted from rupee)

The value of 1 tab in USD (converted from rupee)

Dasutra (30 mg)

Hetero Healthcare Ltd41.230.3
Dapox (30 mg)Ranbaxy Laboratories Ltd62.25

0.38

Prilyxet (30 mg)

Sun Pharmaceutical Industries Ltd41.50.38
Ejalong (30 mg)Emcure Pharmaceuticals Ltd62.27

0.38

Sustinex (30 mg)

Emcure Pharmaceuticals Ltd62.270.38
Xydap (30 mg)Cilpa Limited41.63

0.41

Duralast (30 mg)

Sun Pharmaceutical Industries Ltd41.720.43
Kutub (30 mg)Hetero Healthcare Ltd43.13

0.78

Sustinex (60 mg)

Emcure Pharmaceuticals Ltd63.210.54
Dasutra (60 mg)Hetero Healthcare Ltd42.33

0.58

Kutub (60 mg)

Hetero Healthcare Ltd42.330.58
Duralast (60 mg)Sun Pharmaceutical Industries Ltd42.38

0.59

The prices listed above are submitted for information purposes only and may not match the factual price at which they are sold. The tabs value may vary depending on many factors, such as manufacturer, local taxes, and the rupee / dollar exchange rate.

Those, who want to purchase dapoxetine abroad should ask Google «where can I buy dapoxetine». For most chemists, prescribing information is not needed. A purchaser should be sure that the drug store is reputable and sells qualitative product. Always check the legitimacy of the drug store and the drug certificate.

How to Get Dapoxetine Without Prescription?

Online storeOur online pharmacy ViagraBit offers a simple way out for those who rack their brains about how to get dapoxetine. It is available in our drugstore under different brand names without prescription at a fair price. Quick shipment and big discounts make the purchase easy, safe, and comfortable. Forget about bank payment reducing, choose anonymous, which is a quick and safe way of payment and get benefits: -35% off your order for bitcoin paying!

The most optimal dosage of Priligy 60 mg is available in various amounts in the package: from a trial pack (10 tabs) which is convenient for beginners and drug effect testers, to wholesale package (500 tabs) for regular patients.

In our wide assortment there are drugs for PE and ED cure: Cialis, Stendra, and many others. A wide choice of the active ingredients will help to select the most effective preparation for the best curing effect.

Our prices are the cheapest because we contact Indian laboratories directly and sell the Indian generic drugs in the US. This way is maximally comfortable for customers.

Ordering the drugs from our chemists, you avoid possible problems which may occur with customs control. Our packages go through customs without difficulties. The general time of shipment may take 7-18 days.

Choosing the best preparation for the treatment of such delicate problems demands a lot of time. By choosing our chemistry, you save both your money and time! Our constant purchasers are satisfied with our services and our community grows!

We guarantee that our products are top quality and completely risk-free. Try for yourself how the modern PE and ED drugs increase libido, prolong sexual intercourse, and fill up life with bright emotions. Cure PE and ED with our chemists!

Avanafil: Dosages, Side Effects, Interaction

Avanafil: Dosages, Side Effects, Interaction

Less known analog of popular drugs against erectile dysfunction Stendra is just as good as them. The remedy contains the active ingredient avanafil which helps men get a stable erection whenever they want and feel more confident in bed with their partner. The main benefit: it works even quicker than Cialis, kicking in during 15 minutes from intake.

Even though the majority of men are uncomfortable with their sex lives from time to time, the first symptoms of erectile dysfunction (further referred to as ED) are not a prison sentence. Still, with due care and attention to your men’s health and with the support of specially designed tablets, you can keep such issues to a minimum.

There are a number of distinguished ED medications on the market: Viagra (sildenafil), Levitra (vardenafil), and Cialis (tadalafil) are the most popular and used ones. Avanafil is not as well-known as them, but it isn’t less effective. In some cases, it works even better than those drugs and that’s why may be more suitable for a particular person.

What Is Avanafil?

Avanafil is a PDE5 inhibitor (here and below – phosphodiesterase type 5 inhibitor) widely used for erectile dysfunction treatment. It is a relatively new remedy, the production of which was started only in 2013 by the American pharmaceutical company Vivus Inc.

It has a pretty similar mechanism of action to other PDE5 inhibitors: blood flow to the penile chambers is increasing due to the nitric oxide release and smooth muscles of cavernous bodies’ relaxation. Those substances maintain an erection and help men to improve their performance during intercourse. Avanafil works only in the case of sexual arousal, so it will not cause an erection in everyday life without any reason.
Avanafil: Dosages, Side Effects, Interaction

Available Avanafil Brands

This ingredient is an integral part of Stendra and Spedra medications manufactured by Vivus. Stendra is common in the American market, while Spedra is promoted by the company’s partner, Menarini Group, in 40 European countries, Australia and New Zealand.

Apart from Vivus, there is more than one manufacturer in India which produces so-called generic Stendra. At first sight, such products compare favorably with brand ones because of their lower price. Here you have no guarantee of the high-grade quality – unoriginal drugs may be useless or even harmful to human health. The customer indeed pays a bit more for the well-established brands, but he will be sure of the 100% remedy’s efficiency.

Dosages and Forms

AvanafilAvanafil is available in both online and land-based pharmacies in three forms:

  • 50 mg tablets;
  • 100 mg tablets;
  • 200 mg tablets.

The average starting dose is 100 mg. It may be adjusted in accordance with the individual differences of each man. If you don’t feel much effect or your tolerability has risen, you may increase the dosage up to 200 mg.

Decrease the drug serving to 50 mg if you are taking alpha-blockers or other medications which don’t interact very well with avanafil. Also, it may be reduced due to particular health conditions. The dosage below 50 mg doesn’t provide a benefit, so there is no sense to take less.

Can I Take Avanafil?

Now that you figured out what is avanafil, you should ensure that this component is safe for your body. The one crucial restriction is as follows: Stendra is prohibited for people who are allergic to its components. A man should also consult a doctor before using if he has:

  • heart malfunctions or recent surgery, stroke or another serious problem with the cardiovascular system;
  • fluctuations of blood pressure or permanently high or low pressure;
  • angina and breathing issues;
  • liver and kidney diseases;
  • various blood disorders;
  • serious vision impairment;
  • a stomach ulcer;
  • penis deformity.

Usually, avanafil is well-tolerated, so people without serious health problems may take it safely. It is worth noting that Stendra and Spedra are not intended for women and their impact on pregnant hasn’t been studied yet.

How to Take Avanafil Pills?

ErectionIf you discussed the feasibility of the drug’s usage with your doctor and he or she has approved this solution, go ahead and follow your prescription. Take the serving specified there and don’t change your dose drastically without contacting a doctor.

Avanafil pills are usually taken with a small amount of liquid; the number of tablets depends on the medicine’s form and dosage. The manufacturer states that the time of the last meal doesn’t matter but experts recommend using the drug on an empty stomach. This way, the substance has better solubility, and the body absorbs it quicker. The erection will be forthcoming.

It is preferable to take avanafil in advance: at least 30-60 minutes before sex. You will achieve an erection when you feel sexual arousal – an indispensable condition for a success. At the end of intercourse, your penis will return to its regular state.

Do not take drugs containing avanafil more than once a day. Let 24 hours pass between the usages.

Side Effects

Even though Stendra is safe for a healthy person, some side effects may occur, especially at the initial stages of the treatment. The majority of them don’t require medical care and disappear after the body gets used to the medicine. However, they bring sort of discomfort, so you should be aware of what may happen after your first use and be ready for that.

The other group of possible negative reactions may be dangerous for your body; in this case, you should stop the treatment and contact your doctor.

Common

The most widely spread unwanted effects affecting the patients are:

Those which need medical attention

Those which do not need medical attention

Blurred vision
Dizziness
TinnitusFlushing
Heart rhythm disruptionsFever
HeadacheSore throat
Muscle painStuffy nose
Feeling of warmth

Rare

These effects are very seldom, so you should worry less about them. Some men reported about such issues, so they also have to be listed:

Those which need medical attention

Those which do not need medical attention

Back, bladder, arm, jaw, genitals, chest or other body parts’ pain

Indigestion or diarrhea
Blood in the urine, pain or discomfort during urination, enuresis

Cough

Breathing difficulties or chest tightness

Sweating or shivering
Vomiting and nausea

Anxiety

Fatigue and weakness

Unusual drowsiness
Unexpected weight gain or loss

Muscle spasms

Increased appetite

Overdose

PoisoningDo not take serving more than 200 mg per day. It may cause an overdose and you will require medical help. If you noticed symptoms of poisoning of yourself or another person, call the local Poison Control Center or an ambulance to receive emergency care.

Before the ambulance arrives, try to remove the drug surplus from the body through stomach pumping and providing the injured with a safe environment.

Interactions

You may notice the enhancement of particular side effects if it is taken in combination with some food, medications, or beverages. To minimize risks, avoid the products listed above and fully enjoy your sexual experience without backfire.

Interaction of Avanafil with Food

Alcohol and grapefruit juiceDrugs containing avanafil may be used before, during, or after a meal according to the official instructions. The only product affecting the person in a negative way together with Spedra or Stendra is grapefruit. So, avoid drinking grapefruit juice or eating salads, desserts, or the other dishes containing it, as it can cause an adverse effect.

All other products are acceptable while taking avanafil medication. However, the drug takes effect quicker if you refrain from food a couple hours before using it.

Avanafil and Alcohol Drinks

It is not recommended to mix alcohol and avanafil. As you may know, alcohol in high dosages prevents erection even in young men. Another threat of this combination is an increase of common side effect probability. Stendra + alcohol is not dangerous, though. Therefore, it is your choice whether to drink such beverages before or after taking avanafil, but limit consumption to a couple glasses of beer or wine and no more.

Other Drugs and Avanafil

Avanafil is prohibited to use with riociguat (Adempas) and nitrates like nitroglycerin (Nitromist, Nitro-Dur, Minitran), isosorbide dinitrate (Dilatrate-SR, Isordil), isosorbide mononitrate (Monoket) etc. Such medications are often taken for cardiovascular diseases treatment. Also, they may be supplied in various forms including pills, sprays, pastes, and so on. If you don’t know whether your medicines contain nitrates, ask your doctor. Do not take Spedra together with these drugs, as it is unsafe for your health.

Some recreational drugs also contain nitrates. Such substances as amyl nitrate and butyl nitrate are known better for their street name “poppers” and are not compatible with avanafil.

Do not combine avanafil with other PDE5 inhibitors such as sildenafil, tadalafil, or vardenafil. The most widespread brand names for them are Viagra, Cialis, Levitra, Staxyn, Revatio, and Adcirca.

Before starting the treatment, inform your doctor about all medicines you take.

Here is the list of those which require special attention:

  • antibiotics (clarithromycin, erythromycin, telithromycin);
  • immune supportive medicines used in case of HIV or AIDS (atazanavir, indinavir, saquinavir);
  • antifungal drugs (ketoconazole, itraconazole);
  • remedies against hepatitis C (boceprevir, telaprevir);
  • alpha blockers (alfuzosin, prazosin, terazosin);
  • medications for high blood pressure (nefazodone, verapamil).

Take into account that even some dietary supplements, minerals, and vitamins may influence avanafil’s effect, so be careful while using those together with the remedy.

Other Avanafil Alternatives

The list of similar substances to avanafil includes sildenafil (Viagra), tadalafil (Cialis), vardenafil (Levitra), and dapoxetine (Priligy). The first established brand name among those is Viagra by the Pfizer company. The other two emerged later and are slightly different from it. Let’s compare those medicines with avanafil.

Avanafil Versus Viagra Sildenafil

Many people make their choice based on the question “How long does it last” applicable to each of the ED drugs. To compare avanafil vs sildenafil, the first one has indisputable advantages: it lasts 1-2 hours longer (6 hours of Stendra’s duration against of 4-5 Viagra’s) and kicks in quicker (15-20 minutes vs 30 minutes respectively). Food doesn’t influence avanafil’s effect, so it can be taken with the meal, while sildenafil’s effect may be delayed if used together with food.

The side effects inherent to these drugs are pretty similar. However, Stendra commonly causes nasal congestion and runny nose, while Viagra more often becomes a reason for indigestion.

Avanafil vs Cialis

CialisCialis is famous for its super durability due to its longer half-life. In comparison of avanafil vs Cialis Stendra is losing in effect’s lasting: it works for 6 hours on the average while Cialis lasts up to 36 hours. As for kicking in, the drugs are almost equal and both are resistant to food.

The most typical side effects for Stendra are facial flushing, headache, and stuffy nose. For Cialis – headache and indigestion. Both drugs are cheaper than Viagra, which could be a major cause for purchasing it.

Users’ Reviews

Apart from scientific studies proving the efficiency of the drug, it is important to know what real people say about avanafil’s action. The best way to express your impressions is to write a customer review.

The majority of users are satisfied with both Stendra and Spedra and confirm its efficiency. They say the drug helped them to return their virility back by maintaining stable and durable erection within intercourse. Some customers notice avanafil suits them even better than similar medicines. There are few reports about minor side effects, but most men feel good after taking Stendra.

Buy Avanafil OTC Online

Online pharmacyIf you stumble upon an ED issue for the first time, you may wonder where to buy such remedies over the counter. Stendra, Spedra, and other drugs such as Viagra, Cialis, and Levitra are available in online pharmacies without a prescription. ViagraBit is one of them and has some benefits over the others.

Why choose us? We provide fast and safe shipping throughout the USA within 10-18 days. An express delivery option speeds up the process, and you can receive the package within 7-10 days after ordering. Track our special offers: you can get 35% discount while using bitcoins while paying.

Cialis Dosage

Cialis Dosage

Cialis is a drug that, thanks to its low price and long duration of action, has gained a quite wide popularity. But before you buy Cialis, it is worth to get acquainted with its dosages and way of acting. In this case, you can find the best option for yourself.

Cialis is a drug that not only improves the erection, but also allows man to maintain the natural frequency of sexual activity.

This medicine is effective in all cases of erectile dysfunction, caused by circulatory disorders. Cialis is simple and convenient in use, has a fairly long-term effect with almost no side effects. The effect of the drug is mild and harmonious, since it does not cause excitation, but strengthens it. This means that it will work exactly when a man needs it. Below is some useful information about this ED treatment medicine.

Cialis Tadalafil Uses

The use of Cialis causes relaxation of the smooth muscles in cavernous bodies of penis and improving blood circulation in it. When the excitation happens, the blood freely and quickly fills the cavernous body and in result man have a stable strong erection. Cialis also blocks the PDE5 enzyme, which causes the stop of erection. Thus, men with short-term and unstable erection due to the drug can have a full-fledged sex. Also this medicine allows to:

  • maintain an erection during sex;
  • enjoy the sexual intercourse and bring pleasure to a partner;
  • get positive emotions and has no doubt in own abilities;
  • prolong the sexual intercourse as much as necessary.

Cialis Dosage

What Cialis Dosages Are Available

Most men who use Cialis take the 20 mg tablets. This is the standard dosage, which is suitable in 80% of all erectile dysfunction cases. The 20 mg Cialis dosage is the acceptable maximum for per day use. This dosage helps even in the severe cases of ED. If desired, the dosage can be reduced. The tablets are also available in dosage of 2.5, 5, 10 mg. It is also important to remember that Cialis is active for 36 hours, so taking it very often is not recommended. In some severe cases, the everyday use is possible, but not for a long period.

Before buying the drug with the maximum dosage you need to consult with a doctor, especially if you have problems with heart or blood vessels. Until age 18, this medicine should not be taken.

Who Should Take Cialis 5 mg Daily?

Cialis 5 mgThe effect depends directly from the dose. The young men (19-45 years old) who have minor and rare problems with erection should not take a tablet of 20 mg. It will be enough to take a small dosage – 5 mg.

The minimum dosage is also indicated for men with kidney failure. With this disease, the effect of Cialis becomes faster and stronger, so the dosage should to be minimal. In some cases, the tablet should be divided on a half.

Cialis 10 mg Effects

The Cialis 10 mg it is an average dose and its action doesn’t differ from the action of drug in another dosage. The difference is only in the power of effect. The 10 mg is the best choice for young men who have experience erectile problems rarely and wish “to be reinsured”. Also this dosage is well suitable for men who taking Cialis regularly.

Can I Take Cialis 20 mg Pills

The 20 mg is the most typical dosage which is suitable for almost all men. It is desirable to start taking this drug exactly with this dosage, if there are no contraindications and related diseases. Before use, the consultation with doctor and following his instructions are necessary if:

  • during the last three months, a man has a myocardial infarction;
  • hypotension or poorly controlled hypertension;
  • during the last 6 months there was a stroke;
  • cardiac failure;
  • severe heart rhythm disturbances;
  • propensity to priapism;
  • cardiac angina.

Who Needs to Take Cialis 80 mg Tabs?

Cialis tabsThe maximum dosage of the active ingredient Tadalafil is 20 mg per day, exceeding this dose may be dangerous to health.

In rare cases of very severe erectile dysfunction, Black Cialis 80 mg can be used. It is an extremely potent drug, its action lasts more than 40 hours and it should be used wisely. You cannot eat fatty foods and drink alcohol, and it isn’t recommended to sit behind the wheel of the car after taking the Cialis 80 mg.

Do Cialis Dosages Depend on Weight and Age

The choice of dosage depends on the severity of erectile dysfunction and the general state of human health. Age and weight of a man does not matter. The drug can be taken at the beginning in minimum dosage, but only if the state of health is satisfactory. In the presence of chronic diseases, especially heart disease and kidney failure, it is important to agree the treatment choice and its dosage with a doctor.

Men from 65 years old with a normal state of health usually take the 20 mg tablets. The smaller dosages may be less effective, since slow metabolism can reduce the effect of drug.

Why Cialis Doses Different from Viagra’s One?

Cialis and Viagra have different active components. For Viagra it is sildenafil, and for Cialis it is tadalafil. That is why the dosage is different, and Viagra has a larger amount of active component. The difference between these drugs is also in their action. The Viagra is stronger, but lasts about 4 hours. The Cialis is effective up to a day and a half, but this drug is more mildly. For men with a severe form of erectile dysfunction is better to use Viagra in a big dosage (standard 100 mg or maximum 200 mg).

How Often Can I Take Cialis Tablets?

Stress for heartThe Cialis can be taken per day, but to do this every day, is not recommended in order to avoid excessive stress for heart. Since the drug works 36 hours, to take it every day is not necessary.

When to Take Cialis for the Best Results?

You can take Cialis at any time, but it is important to remember that when this medicine is combined with fatty food, the absorption will be slower (up to 1.5 hours).

What if My Current Dosage Doesn’t Work?

If a man began to take the drug with a minimum dosage, then it can be increased to 20 mg. If even in this case there is no effect, the Cialis intake should be stopped. This treatment does not make sense if ED caused not by vascular disorders, but by other causes. If Cialis does not help, you need to see a doctor.

Can Women Use Male Cialis?

There is no info about that the Male Cialis can be used by women. It is intended only for men, so on women body it will cause no effect. For women, there is a specifical Female Cialis, but before purchase it, you should consult with your doctor.

How to Buy Cheap Cialis Online?

Online storeAll drugs which treat an erectile dysfunction usually have the fairly high price. Cialis favorably differs from them in this, and its price is available to most men. It can be even more advantageously purchased on our ViagraBit website in any dosage. The cost of drug can be reduced in 35%, if to pay for it in Bitcoins.

Our company will deliver your order in any city of USA in one week term. If the order cost bigger than $150 the delivery will be free. Also at ViagraBit online store there are also other drugs which can help with ED, such as Viagra, Kamagra, etc.

Viagra Side Effects

Viagra Side Effects

In this article you read full list of common, rare and serious Viagra side effects. Viagra Intake with greasy food, alcohol drinks and other drugs. Do side effects depend on Viagra type?

Many older men dream to return the sexual activity which used to be at young age, and this is normal. Healthy lifestyle prolongs man’s power, but do not guarantee it.

Viagra helps to feel sex satisfaction of a young and full of energy man. Still, patients should be aware of accompanied symptoms.

What Are Viagra Side Effects?

Viagra (Sildenafil) is a drug used for erectile dysfunction and pulmonary hypertension cure.

It may call light short term side effects. Usually they go away as soon as organism gets used to the new drug. Severe adverse symptoms rarely bother, but are also known.

The drug improves insulin sensitivity in people with prediabetes and so can be taken by diabetics but under the supervision of physician, especially if heart or concomitant diseases are presented too. The pills do not provoke skin cancer. They may convert fat cells and promote weight loss.

Common Side Effects

MajorMinor
FaintingNightmares
IndigestionRed eyes
Chest painConcentration problems
ItchThirst
StuporHearing loss
Painful urinationVision loss
Frequent urinationBlue vision
Blood in urineUlcers on skin

Rare

MajorMinor
Bloody noseLeg pain or numbness
Muscles painInadequacy
DiarrheaAnxiety
Red skinLiver injury
Nasal problemsEmesis
SweatingEarache
Trouble breathingMood disorders
SleeplessnessCough

Expired Viagra and Side Effects

Expired Viagra is less effective and does not call other side symptoms but those which took place during its effective period. To save the pills from early expiration put them in a refrigerator. Cold prevents molecular breakdown and helps to prolong Viagra’s activity. Out of date product will be absolutely inert in 5 years.

Viagra side effects

Long Term Viagra Side Effects

Long term effects require medical check up. Severe symptoms which bother the very next day might lead to serious health changes. Healthcare provider should correct the dose or suggest switching the preparation depending on Viagra side symptoms and patient’s health condition.

Side Effects Depending on Viagra Type

Viagra is produced in different forms (gel, jelly, oral pills, spray) and sold under various trademarks: Viagra Gold, Viagra Soft, Viagra Gold Max etc. They all work similarly and consist of the same active agent. However, there are differences in period of effectiveness, the time when they start working and possible adverse symptoms.

For example, Viagra and Kamagra contain the same active ingredient Sildenafil. But users marked that Viagra vs Kamagra side effects are less noticeable. Due to different dosages, forms and effectiveness respectfully, Kamagra calls priapism, headache, «seeing blue» side effects more often than Viagra.

For choosing the most suitable Sildenafil drug appeal your medical consultant.

Red Viagra Sildenafil

Red ViagraRed Viagra is a powerful remedy for erectile dysfunction cure with higher concentration of the active substance. It is approved by Food and Drug Administration (FDA) and based on Sildenafil plus 100% natural components. Among strong effect the capsule may call dangerous side effects like:

  • allergy (rash, itch, puffy face, swollen tongue and lips);
  • breathing problems;
  • hearing impairment;
  • vision changes (cloudy vision, inability to distinguish blue and green colors);
  • abnormal heart rate;
  • seizures;
  • long-lasting erection.

Mild reactions may take the form in:

  • stomach upsets;
  • blushing;
  • headache;
  • nasal disorders.

The medicine must be taken under the supervision of professional representative with detailed informing by patient about his health condition.

Female Viagra

Female ViagraThe problem of lost sex desire bothers the majority of females after depression caused by bad quality of past relations. Female Viagra, or «pink Viagra», is a drug for treating female sexual dysfunction. It was developed as an antidepressant pill which works on woman’s brain. It was certified by FDA despite numerous and severe side effects. Among the most spread ones are:

  • somnolence;
  • blood pressure drops;
  • dizziness;
  • vomiting.

Too much alcohol during the cure is strictly forbidden due to rising the risk of unwanted side symptoms. Also, the preparation highly interacts with other drugs (birth control pills and many more). Nevertheless, medical testimonials showed successful statistics of using the new revolutionary remedy in Hypoactive Sexual Desire Disorder treatment which affects every third woman in the USA.

Herbal Form

People who want to stay away from medications give preference to herbs. At first glance, buying herbal Viagra a consumer gets herbs and well-known Sildenafil. But barely who knows what are other compounds. FDA in the USA does not regulate the herbs supplements, therefore this product is assumed as not safe and extremely unwelcome.

The danger of herbal form lies in lack of facts how the herbs affect blood vessels. Highly likely that unproven medicine may call multiple side effects and increase the risk of heart attack. Constant doctor assistance must be mandatory for those who feel temptation to try this form.

What if I Mix Viagra And …

Grapefruit and grapefruit juiceNot without a reason Viagra should be taken under the supervision of the medical representative. Ordinary food may drastically interact with Viagra. The following nourishments list is worthy to pay attention to:

  1. Beware of taking Viagra with grapefruit and grapefruit juice. This fruit has been found culpable in thwarting the breakdown of the pills and leads to high concentration of the active ingredient in the body. Hence, together with Viagra it causes next symptoms:
  • blushing of the skin;
  • migraine;
  • blood pressure dropping;
  • dizzy feeling.
  1.  Herbal supplements. In 2015 FDA has announced at least 25 herb remedies which contain real active ingredients as Viagra and other ED medications. Some plants are hyperactive. Supplements do not belong to prescription preparations group, and that is a treat. No one knows what exactly is inside. Better do not use herbs, especially when not needed.
  2.  Caffeinated drinks. There are no scientific studies on this matter, but users who excess caffeine marked worsening Viagra action. Erection problems may appear because caffeine constricts blood vessels which contradicts to drug action. Therefore, it’s better discuss with healthcare provider the feasibility of using tea, coffee, coca-cola and other caffeinated products in daily diet.

So, if these products exist in your regular ration, medical consultation is necessary.

Alcohol

Chronic alcoholism is a common reason of ED problems. Patients should refrain from mixing large doses of alcohol with Viagra. It is explained by their similar reactions: they both widen blood vessels and increase blood circulation. Joining will lead to high risk of unwanted symptoms like:

  • low blood pressure when getting up;
  • irregular heart beat;
  • lightheadedness;
  • weakness.

Alcoholic liquid decreases blood in the phallus which makes circulation much more complicated. Only low dose is acceptable: no more than 2-3 units of wine or beer. Limiting drinking is not only advisable but recommended for overcoming such ED problems as premature ejaculation, loss of sexual desire and exertion achieving orgasm. Therefore, Viagra and alcohol usage is forbidden.

Fatty Foods

Fatty foodsIdeally patients should take Viagra on empty stomach. When it is taken after food which is rich in fats, it works slower. It is explained by the chemical reaction of the drug which starts its action after absorption through the stomach and intestinal tract into the blood. Only when the tab components reach the bloodstream they start working. The duration of high fat meal digestion process is long enough and that causes the delay of Viagra activity.

Other Drugs

Viagra drastically interacts with several drug groups. Refrain from using it or visit personal healthcare provider for receiving an individual scheme of cure if you use the following medicines:

  • α-blockers;
  • antibiotics;
  • antihypertensives;
  • nitrates;
  • CYP3A4 inhibitors;
  • PDE5 inhibitors.

Complete list of drug interactions you can receive at medical center. Mixing recreational drugs with Viagra is firmly forbidden.

How to Reduce the Risk of Viagra Side Effects?

The best way to reduce the risk of Viagra side effects is avoiding overdose and using it under the supervision of the medical representative. Specialists work out individual scheme of treatment, tell about effect of Viagra and how long it lasts, help with providing complete instruction about dosage and side effects. Viagra should be used on as-necessary basis, therefore do not use it if you do not need it. Males without ED must not use the drug.

There are a few simple steps which help to overcome light symptoms with home remedies:

  1. Headache: use headache tablets and drink a lot of water.
  2. Blushing: put a cold cloth on the face, cool the room, take a deep breath and relax.
  3. Heartburn and stomach upsets: use over-the-counter tabs.
  4. Eyes problems: escape bright lights, do not drive a vehicle.

What ED Pills Have Less Side Effects?

CialisAccording to medical results, Viagra is the most effective drug for ED but it also has a higher rate of side effects than other medications. Males who are concerned about thinkable unwanted symptoms may wish to start on Cialis with active ingredient Tadalafil. It is approved for treatment of enlarged prostate and can be used every day.

Side effects do not always happen during the cure. Some men want to feel a stronger effect even if mild symptoms appear sometimes. The mix of Dapoxetine and Tadalafil is called Tadapox. The combination of Sildenafil and Dapoxetine has a name Super P Force. Both drugs provide more powerful effect. 

ViagraBit sells the best quality generic drugs. On our site you can find cheap analogues of Viagra, Levitra, Cialis, Super P Force and other ED drugs. In our assortment there are medications in various forms and convenient dosages (25 mg, 50 mg, 100, mg, 150 mg, 200 mg). Estimate the benefits and make a good deal today!

Erectile Dysfunction: Definition and Causes

Erectile Dysfunction: Definition and Causes

Some men seldom talk about their erectile dysfunction problem with their partner because they feel ashamed of the fact that they’re underperforming in bed. Sometimes this fear devours their happiness, and a person risks losing his partner to someone else because of the long series of premature sex involved. Find out more about reasons have ED disease.

What Is Erectile Dysfunction?

Erectile dysfunction (ED) is very common among many people and is also treatable. And sometimes finding difficulty keeping erect means a person has a serious health problem, which means a doctor’s opinion and supervision is crucial. Also known as impotence, erectile dysfunction is a condition where a man has trouble achieving or sustaining an erection during sexual intercourse. What causes it? This may occur due to reasons like lack of sexual desire or low supply of libido in a partner.

Other things that cause ED include psychological, emotional, and physiologic conditions that alter a person’s ability to fully indulge themselves in sex.

Can It Happen to Everyone?

ED can affect everyone, but it’s mostly common among elderly men staggering. Although the occasion of erectile dysfunction frequently occurs as men age, many men go through life without exhibiting any serious difficulties in keeping and getting an erection. The table below shows a clear illustration of the percentage of men with erectile dysfunction arranged by age group. About 15 to 30 million men suffer from erectile dysfunction around the US, which leaves a fair number of the country’s men population unaffected. Some experience partial or total sexual dysfunction when enjoying sex with their partner and such incidents may arise due to overindulgence in alcohol, severe stress or fatigue, and side-effects from some medications.

AgePercentage
20-298 %
30-3912 %
40-4939 %
50-5948 %
60-6957 %
70-7967 %

In situations where medications appear to be the cause, substituting another drug or changing dosage often subsides the issue. Also, the key to banishing ED in most men is to follow the general health advice given by the doctor, thus eating a healthy and balanced diet and doing some regular body exercise.
Erectile dysfunction definition and causes

Which Symptoms Has This Disease?

Some of the frequently reported symptoms of ED include reduced sexual interest and low libido. Some patients also show signs of nerve damage, some are diabetic, and others suffer from a heart disease which somehow alters their resilience in performing long-lasting sex with a partner. Also worth knowing, erectile dysfunction occurs in various ways. Many who suffer from ED are unable to sustain a boner at all, while others do so but fail to maintain it for a sufficient period. Others can elicit an erection but acquire a soft erection, which is hard to facilitate any deep penetration. Some can perform but lack the ability to enjoy the experience because of low sensitivity and insufficient rigidity. Some other people lack the ability to have sex, despite their deep desire and passion for intimacy.

Are Erectile Dysfunction and Impotence Different?

ED and impotence bear similar characteristics but are not the same thing. Erectile dysfunction delves much to explain a series of sexual difficulties that are treatable, whereas impotence is seen by many as a sad, permanent condition brought about by weakness or age. Why does happen? This is because impotence is linked with infertility and lack of motility of sperm that would otherwise experience difficulty in procreation.

Erectile dysfunction

In fact, medical professionals find no joy using such subtle medical terms. Many love expanding their knowledge on ED and understanding whether it can be cured.

Is Weak Erection an ED?

Almost every man will experience difficulty with erection at some point in his life. How do you get it? ED can occur due to a variety of temporary factors, like stress or non-chronic fatigue. ED is quite fatal in people, and it takes away a high percentage of a person’s intimacy time, thus leaving the other partner totally unsatisfied. Nevertheless, having scattered episodes during a sexual history torn apart by long periods of normal function doesn’t necessarily mean a person is suffering from erectile dysfunction.

How Many Men Have It?

Statistically, men are at a high risk of experiencing erectile dysfunction sometime in their lives. About 30 million American men, including more than 50 percent of men between the ages of 40 and 70, have erectile dysfunction. Particularly when a man gets older, they risk developing ED, though younger men below 30 years can suffer too due to some health complications.

Erectile Dysfunction Causes

Many factors exist in between that can render someone having erectile dysfunction, even though there are some other few that don’t necessarily pose as a cause. This subtle change of behavior makes ED diagnosis and treatment such a sensitive process. Below is a compiled list showing some of the main triggers for ED in most patients.

Common Reasons

The great variety of men usually experiences erectile dysfunction when put under severe physical or emotional strain. Physical causes are most common in old men, while psychological causes are frequent in young men. On the other hand, medications cause about 35% of all erectile dysfunction cases. And various diseases account for up to 75% of people with erectile dysfunction, 35% of this group being mostly diabetic patients.

In fact, some of the common reasons for ED occurrence in men are highlighted below.

  • high cholesterol;
  • Obesity in menobesity;
  • low testosterone;
  • drinking excessive alcohol, smoking or drug abuse;
  • nervous system diseases like multiple sclerosis;
  • heart disease;
  • chronic depression or anxiety;
  • physical issues, like enlarged prostate and other circulatory system difficulties;
  • psychological issues, such as stress from a relationship;
  • some side effects of certain prescribed medications and more.

Aspirin and Ibuprofen

Since pain relievers like ibuprofen and aspirin are effective at combating heart disease, researchers were determined the drugs could treat ED since the condition is associated with heart disease and poor circulation. However, the result of a more recent study showed otherwise, and it suggested that the NSAIDs drugs actually hurt men’s sexual function.

NSAIDs (nonsteroidal anti-inflammatory drugs) is another generic definition for pain relievers, and the drugs are widely considered safe for everyday use. But for someone struggling with ED symptoms and isn’t getting enough sex, the doctor may sometimes change the pain relieving method with a different prescription drug. In fact, men are 2.4 times likely to suffer from erectile dysfunction if they frequently take pain relievers, which means a patient with ED shouldn’t use such drugs.

High Cholesterol

Your body cholesterol levels can affect the efficiency of your erections. Many cases of ED occur due to impaired blood flow to the penis. Some medications that treat erectile dysfunction, like Viagra, help the smooth muscle cells lining the blood vessels to relax so that blood can flow across more easily. A man with high cholesterol levels, not only is his cardiac circulation impaired, but also his blood flow across the body is impaired as well which may affect erection quality.

High blood cholesterolMany doctors consider erectile dysfunction to be a kind of «canary in the coal mine» frequent among men under 40. And many times, he or she may suggest a series of cardiac tests to determine if a patient with ED is at risk for or in the early stages of heart disease.

Changes in diet and exercise are the first treatments offered before others are given top priority. Although if a high level of cholesterol is a known health issue, medications for the same remedy can also be prescribed to treat ED in a subsidiary manner.

Diabetes

The causes of ED in men with diabetes are complex and involve injury to muscle function, nerve, and blood vessel. To get an erection, every man at least needs some healthy body nerves, blood vessels, male hormones, and a strong desire to grow a boner. It’s estimated about 35% to 75% of men who have diabetes are at a high risk of getting ED during their lifetime. In fact, men with diabetes tend to develop ED 10 to 15 years earlier than men with no diabetes. However, men who wish to achieve or maintain an erection can take oral prescriptions like Sildenafil (Viagra, Revatio), Avanafil (Stendra), Tadalafil (Adcirca, Cialis) or Vardenafil (Staxyn, Levitra). Because most people with diabetes also suffer from heart problems, some of these medications can have a negative effect on health. It’s highly recommended that a person talks to a doctor first to get a safe and effective prescription that will work magic.

Who Is in Risk Zone?

The group of men at a high risk of developing ED are those going past the age of 50. Particularly those who love smoking, drinking a lot of alcohol, and abusing drugs make great candidates of erectile dysfunction. Also, people with obesity, diabetes, kidney disease, heart disease are also at a high risk of developing ED. Living and staying healthy, like a change in lifestyle and proper eating habits, can far reduce and prevent the occurrence of erectile dysfunction in men. This can even yield much more extraordinary results if they constitute some exercises in between. For a patient who is already sick, various forms of medications and treatments exist which can help someone regain their ability to enjoy deep intimacy with a partner to the fullest.

What Kind of Doctor Treats ED?

People with heart disease

The kind of health practitioner ED patients should see may vary depending on the classic appearance of the underlying symptoms. Some psychiatric professionals, highly adept in sexual challenges, are usually recommended the most after clearance with the urologist. The urologist’s job is to examine an ED’s patient physical condition and what’s escalating the symptoms further.
Although sometimes it can be difficult and embarrassing to talk to anyone about sexual health, it’s important to discuss the symptoms of ED with an experienced physician. This would give the doctor a clear-cut approach on how to analyze the problem and clarify whether the symptoms are as a result of other health issues. Thus, when speaking with the doctor, it’s important for someone to talk about their sexual orientation openly and honestly.

The kind of talk a patient shares with his doctor is usually very personal, and some occasions of feeling uncomfortable are very present. All the same, being open and honest while talking to the physician about the symptoms can be helpful in many ways.

What to Expect at the Doctor’s Office

Before visiting the doctor, it’s important to calm down a little bit. This is because once a person is finally inside the health practitioner’s room, the environment there changes fast and without any notice. Before a person gets inside, they should have managed to overcome their worry and biggest shame that could otherwise turn into a circus of embarrassment. Not only should someone be ready to discuss their sex life with their physician, they should also get ready to undergo a thorough physical examination. This can be an examination of the testicles and penis area as well as a prostate exam.

After close-examining the underlying symptoms, the doctor may recommend a period of rest to observe and check whether the symptoms will clear before jumping to the next steps. After the time elapses, a patient should expect much more invasive tests to follow next.

What Other Tests are Issued to Diagnose ED?

Visiting urologist

Urine testing and blood work unfold many underlying health problems and, at the same time, an ultrasound may be initiated to check the viability of erectile function. Other tests the doctor may consider include measuring of a patient’s blood pressure, and examination of the heart because many cases of erectile dysfunction are linked to cardiac problems. If the doctor detects a related disease, it’s vital for a patient to ask for a double therapy. For example, like a lisinopril for heart treatment and Viagra for the salvation and further enhancement of sex life. Patients are forbidden to self-medicate, as improper dosage and a combination of drugs can even result in death if not careful. No matter which symptoms you have or how the condition rarely or frequently occurs, your doctor should be fit to treat the underlying symptoms. He should also prescribe you an effective treatment or enroll you in some therapy sure to make your partner happy next time you’re both in bed! Buy tablets in the online pharmacy ViagraBit with Bitcoins and pay less, get a discount of 25 %!

Premature Ejaculation Definition

Premature Ejaculation Definition

What are some things to help men struggling with PE, and what kinds of drugs can be used as an effective solution? To find the answers you need to beat PE, take a quick look below.

Premature ejaculation (PE) can be a major hurdle to overcome for men all over the world, affecting the most intimate moments of their lives and depleting sexual confidence. However, PE is nothing to be ashamed of. In fact, the disorder is experienced by between 20 and 30 percent of all men at some point in their lives, making it the most common sexual disease. And while there is plenty of myth surrounding it, such as its connection to low testosterone or a small penis, these rumors have little to no scientific basis.

The definition of premature ejaculation describes it as a sexual dysfunction that causes men to ejaculate before or shortly after sexual penetration. It is a serious condition that can produce anxiety in both partners, and lead to long-term trouble for many relationships. While it may seem like a minimal threat at first, it is important to resolve the problem early to avoid patterns of unfulfilling sex.

Why Does Premature Ejaculation Happen?

Doctors are not entirely sure how to pinpoint the reasons PE occurs in some men and not in others. In rare cases, physical causes such as direct injury to the genitals may be the culprit; however, in most cases, it is considered a psychological condition. Nevertheless, this does not mean PE isn’t a serious threat to health, and it should be treated with care.
Cases of PE come in all different shapes and sizes, from men who have remained with a single partner for years, to those who have recently started a new relationship. And while it is commonly associated with young and inexperienced sexual partners, older men suffer from the condition as well. Learning how to overcome PE starts with accepting that everyone is vulnerable.
Premature ejaculation definition

PE Causes

So, why does it happen? Below is a list of some of the more common causes for PE, reported by men who have experienced the condition for themselves. If any of the following descriptions sound familiar to you, seeking treatment should be the next step.

  • a 50-year-old man in a long-term relationship is finding it more and more difficult to control himself in bed. The more he struggles to delay his ejaculation, he inevitably leaves the bed feeling unsatisfied and embarrassed;
  • a young man is now sexually active for the first time in his life; however, he is never able to make it very far in any of his budding relationships. As soon as he moves beyond kissing with any of his dates, he quickly needs to make a trip to the restroom;
  • Depressionfor months, one man in his mid-thirties has stayed away from sex completely. The last time he became intimate with another person, he was embarrassed to admit that he had already ejaculated. Now he is not sure when he will feel confident enough to get back into bed.

What Symptoms Does PE Have?

Premature ejaculation has one central symptom, which is the inability or difficulty to delay ejaculation during times of sexual stimulation. However, this core condition quickly leads to a variety of other symptoms. It is important to remember that PE will affect the psychological state of different men in a variety of ways, and there is no one-size-fits-all description.

Anxiety and depression are the most closely linked effects of those who have long-term PE. As the disorder continues without treatment, negative feelings start to become attached to sex, which can lead to erectile dysfunction.

Can I Delay Premature Ejaculation?

Not all cases of PE require treatment, and many men who experience it only feel its effects in the short term, during times of high stress or other distractions. If you have only suffered from PE in one or two isolated cases, there is no need to worry as it will likely take care of itself in time.

One tried and true option for dealing with PE is to simply masturbate before sex. Relieving tension an hour or two beforehand will leave you feeling generally calmer and not as anxious to perform in bed. If this solution doesn’t initially work, try masturbating as little as 30 minutes beforehand, which should have an even greater effect.

Super P Force pills

However, overcoming chronic PE, which can affect a man for months or years, often requires outside help through the use of drugs or therapy. While some may be able to overcome the disorder through the sheer force of willpower, doing so may be risky and lead to unpredictable results.

Try to Take PE Pills

There are a wide variety of pills on the market today to treat PE. And while many of these options have only been available with doctor approval in the past, some such as Priligy (Dapoxetine), Tadapox and Super P Force are becoming available without prescription. Understanding the unique benefits and side effects of each is important before beginning your own treatment plan, but one good place to start is know how to dose. Find out what is good for PE in the helpful chart below, and which dosages to start from:

TabletDosage
Priligy30 mg
Super P Force25 mg
Tadapox20 mg

Other Solutions to Fight PE

If you are looking for a way to treat your PE today, without a trip to your favorite online pharmacy, there are a surprising number of options. One of the most simple solutions lies in knowing which foods prevent PE, or at least help ease its effects. Asparagus is one such example as it contains high amounts of vitamin E and iodine, which combined help boost testosterone. This will leave you feeling more confident and competent in bed. Another option is blueberries, which help relax the veins in the penis and allow greater blood flow overall.

Also, kegel exercises are another majorly untapped resource for men suffering from PE. Kegel workouts target the pelvic muscles that contract during orgasm, and keeping them fully toned will help lend a greater sense of control during sex. Not sure how to target the right muscle? It is the same one that helps you interrupt the flow during urination.

How Viagra Interacts with Food, Alcohol, Other Medications and Drugs

How Viagra Interacts with Food, Alcohol, Other Medications and Drugs

Want to know all about how Viagra interacts with fatty foods and fruits? Can you drink alcohol and take Viagra? What medications you shouldn’t take with Viagra pills? Read this article!

Viagra is a drug that can be taken safely by patients suffering from erectile dysfunction to help achieve a stronger and firmer erection. For the drug to achieve required results, there are several things an individual needs to take note of before using it.
The issue of how long to wait after taking the drug and will it work weigh on many men’s minds. 25-60 minutes is the timeframe for the drug to work if taken in the recommended manner, at the advised dosage. However, there are several restrictions brought about by some drugs or food interactions that may cause delayed effect of the drug or induce side effects.

For further clarifications contact your healthcare provider or pharmacist.

Viagra Uses

Viagra, generically known as Sildenafil, is one of the most common and safest drugs taken by men for the treatment of erectile dysfunction. You take it in an oral manner, and it works by relaxing the muscles found in the walls of blood vessels allowing more blood to flow to the penis giving a stronger and longer erection.

A Viagra variant can also be used by women experiencing trouble being aroused prior to sexual intercourse. In the same way that it works for men, it also relaxes women’s muscles and allows them to experience normal sexual arousal and inherently, pleasure.

How Viagra Interacts with Food, Alcohol, Other Medications and Drugs

Who Should Take Viagra Pills?

The Viagra pill is a medication for men who suffer from erectile dysfunction and have difficulty achieving a firm erection on their own. Any individual above the age of 18 can safely take the drug. Take note of the drug interactions and effects before taking the Viagra pill. Dose recommendations and effectiveness may differ in separate individuals.

Viagra Interactions

ViagraViagra has several interactions that interfere with the effects of the drug. For example, Viagra should not be taken with any nitrates because this can cause a major drop in blood pressure. Viagra and nitrates both have a relaxing effect on the blood vessels that control the blood flow, therefore, they can enlarge the vessels too much and result in a blood pressure drop.

There are several other medications which cannot be taken together with Viagra. Taking Viagra with or without different foods also has considerable effects on the effective on the it effective use. Viagra should not be crushed in food in any case. Notify your healthcare provider or pharmacist about any medications you are taking.

Intake of Viagra and Food

Is it better to eat before or after taking Viagra? Taking Viagra with food is fine, although the absorption of the drug will be slower, which means it might take longer to work. One food to avoid with Viagra is grapefruit or taking it with any grapefruit extract as it stops the ability of some of the enzymes in the body to break down the active ingredient – Sildenafil. This delays absorption of the drug and will result in delayed effect.

Taking Viagra on Full or Empty Stomach

Viagra on an Empty StomachTaking Viagra with food is not dangerous, however, there is a potential of several interactions that may have an adverse effect on the drug. An individual’s dinner may comprise of different foods depending on the individual’s diet. When an individual takes Viagra on a full stomach they may slow down the effect of the drug. For the drug to be fully effective it needs to be absorbed by the individual’s system and this will take longer as the system is still busy digesting the food while queuing the drug absorption. Food may take up to 2 hours or more to digest. For example, seafood contains fatty acids that take considerable time to digest.

The citrate content in fruit can also affect the effects of Viagra and blocks the desired effect. Furthermore, the meal can have nitrate content which is not to be taken together with Viagra. Whether the food is taken before or after the pill, the effects of slowing down the pill can be experienced with respect to the time the food is ingested and its digesting time.

Taking Viagra on an empty stomach versus taking it on a full stomach is recommended as this allows you to control any possible side effects of the drug more. It also ensures you get the erection you desire in good time and more effectively.

Can I Eat Pomegranate and Grapefruit?

Can you take Viagra with certain foods? Should you take Viagra with food? For peak effect, make sure you don’t eat a few hours before taking Viagra. The directions food must be taken with Viagra are very important with regard to your health. Different fruits may have an effect on Sildenafil’s ability to fix erectile dysfunction. An individual taking Viagra should avoid eating any grapefruit or grapefruit extract products because this can interfere with enzymes that must break down the drug, which causes a delayed effect of the medication. This can potentially increase the side effects of the drug.

Pomegranate juice is said to have a “viagra effect”, as it causes a surge in testosterone and boosts sexual desires. The combination of Viagra and pomegranate is said to be more effective as they mutually reinforce each other. However, caution should be taken when these two are taken together as with all other interactions. Ensure to look out for any side effects and immediately report any adverse effects.

Should You Avoid Fatty Foods?

Viagra taken with high fat, greasy, oily foods may cause the drug take a longer time to work as it limits the absorption of the drug. In order for the Viagra to have desired effects, it needs to be absorbed into the bloodstream so a fatty meal will then delay the absorption as your digestive system is busy working on digesting your food and ultimately delay the effects of the drug. It is better to avoid ingestion of fatty foods when using the Viagra pill.

Nitrates in Meal

Viagra should not be taken with any nitrates! Viagra and nitrates have the same effect of relaxing the muscles of blood vessels controlling the blood flow and can therefore ultimately cause blood pressure to drop. Nitrates in food will then cause the drug to have effects that may include dizziness and being lightheaded due to the blood pressure drop. To avoid these interactions Viagra should ideally be taken on an empty stomach. It is not dangerous to take the drug with food however it is safer and effects are more predictable when taken on an empty stomach.

Mixing Alcohol Drinks and Sildenafil

Are you supposed to drink alcohol while taking Viagra? Viagra is not a great mix with alcohol, the incidence of side effects increases dramatically. Major side effects of Viagra are the same effects that an individual may experience when taking alcohol, therefore, the combination can be dangerous for the patient. Excessive alcohol intake is also known to have a debilitating effect on erection.

How Wine Affects on Viagra Action?

WineOne should not mix Viagra with alcohol. Wine being a form of alcohol will have the same effect as any other alcoholic drink of potentially intensifying the side effects of Viagra. Also, alcohol consumption decreases the blood which stays within your penis, making it harder for you to get an erection.

Interaction of Viagra and Other Medications

Necessary precautions should be taken when using Viagra and other medications together. Viagra causes vasodilation of blood vessels meaning it decreases blood pressure and many interactions with different drugs may pose a danger to the individual. Caution should be taken when mixing Viagra with the following medications:

  • nitrates for blood pressure;
  • wakefulness drugs such as Provigil;
  • antifungals such as Ketoconazole;
  • alpha blockers;
  • St. Johns Wort;
  • stimulants (Ritalin, Adderall).
AdvisedAlcoholFoodNitratesGrapefruitAntifungals
ViagraNoNoLethalDangerousDangerous

Drugs in these classes should not be taken with Viagra due to their ability to either diminish the effect of the drug or to lead to toxic concentrations in the blood.

Antibiotics

AntibioticsSome antibiotics limit the dosage of the Viagra to 25 mg while some require an individual to complete the antibiotic course first before they can use the Viagra pill. Notify your healthcare provider of the antibiotics you are taking for further advice on dosage and Viagra intake.

L-Arginine

L-arginine is a drug for heart and blood vessel conditions that works by decreasing blood pressure and can, therefore, cause blood pressure to go too low when taken along with Viagra.

Warfarin

Warfarin has a blood thinning effect and there is an increased risk of bleeding out for patients who have pulmonary hypertension. For safe use of the Viagra pill notify your healthcare provider of individual’s medical history to be sure if you are supposed to be taking Viagra or not.

What About Drugs?

NitratesMost recreational drugs may contain nitrates and when taken with Viagra can cause a major drop in blood pressure. Nitrates may not interact with Viagra. Ensure you are aware of the drug content before taking it together with Viagra.

Viagra can effectively result in a stronger and longer erection as desired when directions of use are closely followed. Take note of the best food to eat and not to eat with the drug as well as the time after eating one needs to observe for the drug to work. Viagra is a tried and tested method of curing a weak erection. It can even perk up a plant and stop it from wilting according to researchers. Check out our low prices for Viagra and other ED drugs in the same class at viagrabit.com.

Everything You Need to Know About Viagra

Everything You Need to Know About Viagra

Want to know what is Viagra? What are Viagra uses and effects? How Viagra works? Read all answers in this article!

Viagra, the little blue pill. If you’re a man with erectile dysfunction, you’ve probably heard some (or lots) about it, what it’s used for, and have considered trying it or already have.

There are a lot of erectile dysfunction drugs to choose from, and you may also have heard about cheaper generic forms of these drugs. In this article, we give you the information you need about Viagra and its generic form, including how is used, to choose the right solution for you.

What Is Viagra?

Brand-name Viagra, also known by its generic name, Sildenafil, is a medicine used for treating erectile dysfunction (ED) and, in some cases, pulmonary arterial hypertension in men. Its effectiveness is the highest among all erectile dysfunction medications – making it arguably the best. It was the first tab developed for the treatment of erectile dysfunction. In recent years, Viagra has also become popular for recreational use for young men, as it gives them longer erections, though using it recreationally is not recommended.
Everything You Need to Know About Viagra

What Viagra Pills Look Like?

Viagra pills are small blue-color tablets, though they’re often known popularly as sex pills. The brand name Viagra comes with its name stamped on the tablet, while generics are often unmarked but also blue.

Brief History

Erectile DysfunctionThe original story behind male Viagra and its use to treat erectile dysfunction was an accident. Scientists Andrew Bell, David Brown, and Nicholas Terrett at Pfizer were developing the drug with the purpose of treating high blood pressure and other possible heart conditions. These researchers discovered that it was successful in inducing erections, and decided to test it for this use instead. Thus, it was patented as Viagra, and approved by the FDA in 1998. This made it the first oral tablet used for the treatment of erectile dysfunction in the US.

What Is It Made Of?

You know what Viagra does, but what is it made up of? Among the many chemical compounds and processes involved in making it, Viagra’s active ingredients include:

  • microcrystalline cellulose;
  • anhydrous dibasic calcium phosphate;
  • titanium dioxide;
  • croscarmellose sodium;
  • hypromellose;
  • triacetin.

For the most part, Viagra is made from easily soluble parts that are broken down by the liver hours after taking it.

Who Makes Viagra?

PfizerBrand-name Viagra is produced and sold in the US. by Pfizer. The alternative generic form of Viagra though is made by a number of different pharmaceutical companies around the world.

Who Should Use Viagra?

Your doctor can tell you if Viagra is right and safe for you. Men who suffer from erectile dysfunction are usually good candidates for Viagra or a generic form of it. Because Viagra is the most effective ED drug for most men, it is often prescribed first. How effective is it? In most studies, about 80% of men find that it gives some benefits in treating erectile dysfunction. Men who find it does not work or suffer side effects from it will then be prescribed another erectile dysfunction medication, like Cialis or Levitra.

You should not use Viagra if you use another nitrate drug. The combination of most erectile dysfunction drugs and nitrate drugs is one of the biggest dangers of taking Viagra and similar drugs, as it lowers your blood pressure. If you do use a nitrate drug, ask your doctor about possible alternatives. If you have questions about how it may react with other medications you take, also be sure to ask a medical professional. Be sure to follow its directions carefully as well, and take no more than 1-2 doses per day.

There are some common side effects of Viagra, including:

  • Side Effects Of Viagrastomachache;
  • flushing, fever;
  • runny nose;
  • muscle pain;
  • blurry vision.

Viagra Types

Viagra is the brand name of generic Sildenafil. There can be many types of Viagra in the sense that other companies can create generic forms of the same drug either under their own name or just under the banner of “generic sildenafil”.

How Does It Work?

Viagra, Sldenafil, is by definition a PDE5 inhibitor, meaning it inhibits the compound that often decreases blood flow. This allows it to stop the breakdown of cGMP, which is what helps blood flow and gives you an erection. Because it only prevents the premature breakdown of this chemical, it cannot give you an erection if you are not sexually aroused. It simply assists in blood flow occurring and lasting longer. Cialis and Levitra work in much the same way. The main difference in these drugs is their half-life, or how long it takes for them to begin working and how long they last before breaking down in the body. Viagra takes about 2-3 hours to work, which is why it is recommended that you take it a few hours before anticipated sexual activity. It generally lasts about 5 hours after taking it. Other drugs may take a longer or shorter time to begin working and may last less or more time.

This table shows you the properties of each form of sildenafil:

 PropertiesViagraCialisLevitra
Take before sexual activityXXX
Take dailyX
Lasts hoursXX
Lasts up to a few daysX
Effective for most malesX

Does Medicare Cover Viagra?

Viagra PillsBecause erectile dysfunction is not considered a life-threatening condition, it is not covered under traditional Medicare plans. If Viagra, or other similar drugs, are used for other heart conditions, they may be covered by Medicare, but this is rare.

Without medicare coverage, Viagra pills can cost far more than most can afford. When you buy generic Viagra online, not only do these medications tend to be cheaper due to price competition, you can also buy in bulk and in larger doses and cut pills in half. Because Viagra is a prescription drug in the US, you cannot buy in bulk from pharmacies, which adds to the high cost.

Viagra Over the Counter Buying at Online Pharmacy

In the US, Viagra is not currently available as an over the counter drug. It may become an over the counter drug in the US or other countries in the future, but this likely won’t happen until Pfizer’s patent on it expires.

Though it can not be bought over the counter at the moment, it can be bought online and shipped from abroad.

In the US and many other countries around the world, patent laws prevent pharmaceutical companies from producing drugs until the patent expires. This means that only the company that holds the patent can produce these drugs. Viagra is one example of this. In the US, patents are intended to incentivize companies to invest in research and development of new drugs, as it ensures they will be able to make a profit for a few years without competition. However, in the US, many of these patents continuously get extended and these companies can charge customers whatever they like. This is often due to the politics involved in US pharmaceutical companies and the lobbyists they hire to try to get patent extensions. For drugs that are not covered by insurance, like Viagra, this can make affording drugs impossible for some. Most erectile dysfunction drugs all cost a similar amount as well, and none are covered by Medicare.

Online PharmacyIn other countries though, patent laws either don’t exist or they are not granted for as long as those in the US, and rarely if ever extended. In countries with socialized healthcare, these patents often do not last as long because the financial burden would be too great for the government. In such countries, other pharmaceutical companies can begin producing the generic version of these drugs and price competition drives prices lower. That is why you can get many drugs from an online pharmacy. These online pharmacies ship drugs from countries where patents have expired and generic medications are already widely available.

Is It Legal?

In the countries where these drugs ship from, buying them is perfectly legal. Online pharmacies are based in countries where generic medications are regularly made and sold, so it’s as if someone is going to the store abroad for you and sending you the medication in the mail. If you went to these countries themselves, you would also be able to buy them in stores or from doctors.

Causes of Erectile Dysfunction & Facts About Viagra

Medical or psychological problems, or a combination of those issues, as well as certain drugs, can cause erectile dysfunction. Medical conditions that can cause this conduction are generally those that affect blood flow to the penis including diabetes and heart disease. Psychological problems that may have a bearing on this condition include depression, stress, and relationship problems. Other contributors include smoking, drugs (both prescribed and recreational), and alcohol. Greb Free ED Tabs Samples like Viagra, Cialis and Levitra.

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